Macrolide and macrolide-related antibacterial agents

New Macrolide Antibiotic. In Vitro Antibacterial Activity of 9-Propionylmaridomycin

9-Propionylmaridomycin shows in vitro antibacterial activity against grampositive bacteria and has some action on Neisseria gonorrhoeae and Vibrio cholerae, but is generally inactive against many gram-negative rods. This antibiotic exhibits strong activity against clinical isolates of Staphylococcus aureus which are highly resistant to erythromycin or oleandomycin, or both, but which are sensit...

Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants.

Macrolide resistance in Staphylococcus aureus: inducers of macrolide resistance.

Several macrolide-, lincosamide-, and streptogramin B-type (MLS) antibiotics were tested as inducers of erythromycin A (EM)-resistant [(14)C]leucine incorporation. Only 14-membered-ring macrolides having a glycosidically linked 6-deoxy sugar at the C-3 position of the lactone ring and the structurally dissimilar lincosamide, celesticetin, showed inducer activity. Modifications of EM at the C-4'...

The fall of the Macrolide: Macrolide-resistant Mycoplasma pneumoniae

Mycoplasma pneumoniae (M. pneumoniae) is a major cause of community-acquired pneumonia (CAP) in children, accounting for 10-30% of the etiological agents wor ldwide. Yet , the epidemio logy of M. pneumonia-associated CAP in Hong Kong remains unknown for several reasons. First, there is no systemic surveillance of agents causing CAP in place in Hong Kong. Secondly, serology was the mainstay of d...

Chemistry of the immunomodulatory macrolide ascomycin and related analogues.